by: Parent Project Muscular Dystrophy
ReveraGen BioPharma announced the initiation and first patient enrollment in a double-blind, placebo- and prednisone-controlled clinical trial (VBP15-004) of vamorolone, a first-in-class dissociative steroidal anti-inflammatory, in Duchenne.
This VISION-DMD study will enroll approximately 120 patients at ~30 sites in US, Canada, Israel, United Kingdom, Sweden, Australia, Netherlands, Belgium, and Czech Republic.
In publicly released data, six months treatment with vamorolone showed dose-responsive improvements in timed function tests, and improved safety relative to historical comparators treated with glucocorticoids.
ReveraGen’s Update:
ReveraGen Announces First Patient Enrollment in International Pivotal Trial of Vamorolone in Duchenne Muscular Dystrophy
VISION-DMD Study Supported by National Institutes of Health and European Commission Examines Efficacy and Safety of Vamorolone Compared to Placebo and Prednisone
ROCKVILLE – 22 August 2018 – ReveraGen BioPharma, Inc. today announced the initiation and first patient enrollment in a double-blind, placebo- and prednisone-controlled clinical trial (VBP15-004) of vamorolone, a first-in-class dissociative steroidal anti-inflammatory, in Duchenne muscular dystrophy. This VISION-DMD study (clinicaltrials.gov NCT03439670) will enroll approximately 120 patients at ~30 sites in US, Canada, Israel, United Kingdom, Sweden, Australia, Netherlands, Belgium, and Czech Republic.
“This trial builds on the promising preliminary safety and efficacy data in our completed Phase 2a trial of 48 DMD boys”, said Eric Hoffman, Ph.D., CEO of ReveraGen, and study Sponsor. In publicly released data, six months treatment with vamorolone showed dose-responsive improvements in timed function tests, and improved safety relative to historical comparators treated with glucocorticoids.
Glucocorticoids, such as prednisone and deflazacort (Emflaza) are considered standard of care, yet the many side effects of these drugs lead to decreased quality of life of patients and their families. “DMD patients need an alternative to glucocorticoid standard of care, and it is our hope that this new VISION-DMD trial will provide data towards this end,” said Michela Guglieri, M.D., Study Co-Chair and Hon. Consultant in Human Genetics – Neurologist at The Newcastle upon Tyne Hospitals and NHS Foundation Trust in the United Kingdom.
Vamorolone is a first-in-class drug with a novel chemistry that binds to the same receptors as glucocorticoids, but changes the downstream activity of the receptors. This has the potential to ‘dissociate’ the efficacy from safety concerns, as suggested in multiple animal models of chronic inflammatory states, as well as Phase 1 clinical trials in adult volunteers, and the aforementioned Phase 2a study in 48 DMD boys.
Vamorolone has been developed under a venture philanthropy model, with participation in funding and design of studies by 12 international non-profit foundations, US National Institutes of Health, US Department of Defense, and European Commission Horizons 2020 program.
About the VISION-DMD VBP15-004 study.
Boys with DMD that have not yet been treated with glucocorticoids, and who have had their 4th birthday but not yet had their 7th birthday will be randomized to one of four groups: low dose vamorolone (2 mg/kg/day), high dose vamorolone (6 mg/kg/day), prednisone (0.75 mg/kg/day), or placebo. After the initial 24 week treatment period, the prednisone and placebo groups will cross-over to low dose or high dose vamorolone. The second treatment period then has all patients treated for an additional 24 weeks with vamorolone. Clinical outcomes for efficacy include timed function tests and measures of muscle strength and endurance. Clinical outcomes for safety include monitoring of bone changes, weight changes, cataracts, and biomarkers of metabolic disturbances. Enrollment is expected to take about 12 months, with total study duration of about 24 months.
